ca2 influx — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
TN1121	Evocarpine		Apoptosis , cAMP , Anti-infection , Calcium Channel , Antibacterial
	Evocarpine shows antimycobacterial, and vasorelaxant effects, it can inhibit Ca2+ influx through voltage-dependent calcium channels.
T6777	Bay K 8644	(±)-BAY-K-8644,SQ 28,873	Calcium Channel
	Bay K 8644 (SQ 28,873) is a potent, selective activator of L-type Ca2+ channel with IC50 of 17.3 nM.		Calcium Channel
T0370	Pheniramine maleate	Daneral,Inhiston,Trimetose	5-HT Receptor , Histamine Receptor
	Pheniramine maleate (Trimetose), an alkylamine derivative with antihistaminic and vasodilatory properties, binds to histamine H1 receptors, thereby inhibiting phospholipase A2 and production of the endothelium-derived re...		5-HT Receptor , Histamine Receptor
T12234	NMDA-IN-1		NMDAR
	NMDA-IN-1 is a potent and NR2B-selective antagonist of NMDA(NMDA Ki of 0.85 nM; NR2B Ca2+ influx IC50 is 9.7 nM).		NMDAR
TNU0864	HUP30		Potassium Channel , Calcium Channel
	HUP30 is a potent vasodilating agent. HUP30 can stimulate soluble guanylyl cyclase, activate K+ channels, and block extracellular Ca2+ influx.		Potassium Channel , Calcium Channel
T11102	DS16570511		Calcium Channel
	DS16570511 is a novel, cell-permeable inhibitor targeting the mitochondrial calcium uniporter. It effectively blocks the increase in Ca2+ influx dependent on MCU or MICU1 [1].		Calcium Channel
T16687	Pyr3		TRP/TRPV Channel
	Pyr3 is a selective transient receptor potential canonical channel 3 inhibitor. Pyr3 inhibits TRPC3-mediated Ca2+ influx in a dose-dependent manner(IC50 = 700 nM).		TRP/TRPV Channel
T16688	Pyr6	N-[4-[3,5-Bis(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]-3-fluoro-4-pyridinecarboxamide	TRP/TRPV Channel
	Pyr6 (N-[4-[3,5-Bis(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]-3-fluoro-4-pyridinecarboxamide) is a selective TRPC3 inhibitor with IC50 of 0.49 uM(Ca2+ influx inhibition in thapsigargin depleted native RBL-2H3 cells).Pyr6 ...		TRP/TRPV Channel
TN1136	Procyanidin A1	Proanthocyanidin A1	LDL , Calcium Channel , PKC
	Procyanidin A1 (Proanthocyanidin A1) has antiallergic effects, it inhibits degranulation downstream of protein kinase C activation or Ca2+; influx from an internal store in RBL-2H3 cells.		LDL , Calcium Channel , PKC
TN1065	Hirsutine		Apoptosis
	Hirsutine induces apoptosis and is a potent Dengue virus inhibitor exhibiting low cytotoxicity.Hirsutine has anticancer, cardioprotective, anti-hypertensive and anti-arrhythmic activities, it also has vasodilatation acti...		Apoptosis
TN2322	Yangambin		Calcium Channel , PAFR
	Yangambin is a selective antagonist of the cardiovascular effects of platelet activating factor (PAF); it has hypotensive effect, which is probably due to a peripheral vasodilatation that involves, at least, the inhibiti...		Calcium Channel , PAFR
T5120	Rhamnose	6-Deoxyhexopyranose,6-Deoxy-L-mannose,alpha-L-Rhamnose	Calcium Channel , Endogenous Metabolite
	Addition of the Rhamnose (6-Deoxy-L-mannose)-rich polysaccharide, RROP-1, to normal human dermal fibroblasts (NHDFs) and human endothelial cells produced a dose-dependent stimulation of the calcium-signaling pathway, ind...		Calcium Channel , Endogenous Metabolite
T16686	Pyr10		TRP/TRPV Channel
	Pyr10 is a pyrazole derivative and a selective TRP cation 3 inhibitor. Pyr10 has the ability to distinguish between receptor-operated TRPC3 and native stromal interaction molecule 1 (STIM1)/Orai1 channels. Pyr10 inhibits...		TRP/TRPV Channel
T10782	CGP52411	DAPH	EGFR , Beta Amyloid
	CGP52411 is an orally active, and ATP-competitive inhibitor of EGFR (IC50: 0.3 μM). CGP52411 blocks the toxic influx of Ca2+ ions into neuronal cells and dramatically inhibits and reverses the formation of β-amyloid Aβ42...		EGFR , Beta Amyloid
TP1910L1	CALP1 acetate	CALP1 acetate(145224-99-3 free base)	CaMK
	CALP1 acetate is a calmodulin (CaM) agonist (Kd of 88 µM) that binds to the CaM EF-hand/Ca2+-binding site. CALP1 blocks calcium influx and apoptosis (IC50 of 44.78 µM) by inhibiting the open of calcium channel. CALP1 blo...		CaMK
T2711	Chembridge-5861528	TCS 5861528	TRP/TRPV Channel
	Chembridge-5861528 (TCS 5861528) is a TRPA1 channel blocker that antagonizes AITC- and 4-HNE-evoked calcium influx with IC50 values of 14.3 and 18.7 μM, respectively.		TRP/TRPV Channel
T5148	Atosiban acetate	RW22164,Atosiban acetate (90779-69-4 free base),RWJ22164	Oxytocin Receptor , Vasopressin Receptor
	Atosiban acetate (RW22164) is an inhibitor of the hormones oxytocin and vasopressin. It is used as an intravenous medication as a labour repressant (tocolytic) to halt premature labor. Atosiban acetate (RW22164) inhibits...		Oxytocin Receptor , Vasopressin Receptor
T6530	HC-030031	HC030031,TOSLAB 829227	TRP/TRPV Channel
	HC-030031 (TOSLAB 829227) is a potent TRPA1 inhibitor, which antagonizes AITC- and formalin-evoked calcium influx with IC50s of 6.2±0.2 and 5.3±0.2 μM, respectively.		TRP/TRPV Channel
T6S2140	β-Anhydroicaritin	Anhydroicaritin,Beta-Anhydroicaritin	MMP , Others , TNF , Interleukin
	1. β-Anhydroicaritin exhibits immunosuppressive effect on the mouse macrophages stimulated by LPS. 2. β-Anhydroicaritin phytosomes can inhibit enhanced bone turnover induced by ovariectomy, improve BMD the biomechanical ...		MMP , Others , TNF , Interleukin
T11480	GSK205		Others
	GSK205 is a selective TRPV4 antagonist (IC50: 4.19 μM) for inhibiting TRPV4-mediated Ca2+ influx.		Others